Kevan M Shokat Selected Research

Carbonyl Reductase (NADPH)

10/2017	Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin in Breast Cancer Treatment.
8/2012	Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide.
2/2011	Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells.

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Kevan M Shokat Research Topics

Disease

61	Neoplasms (Cancer) 01/2022 - 08/2002
8	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 04/2008
8	Glioma (Gliomas) 01/2017 - 12/2003
6	COVID-19 03/2021 - 01/2020
6	Breast Neoplasms (Breast Cancer) 12/2019 - 10/2008
5	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 10/2007
5	Infections 01/2020 - 04/2013
2	Starvation 09/2021 - 02/2003
2	Carcinoma (Carcinomatosis) 01/2019 - 01/2016
2	Genomic Instability 01/2019 - 07/2013
2	Parkinson Disease (Parkinson's Disease) 10/2017 - 08/2013
2	Colorectal Neoplasms (Colorectal Cancer) 01/2017 - 12/2012
2	Triple Negative Breast Neoplasms 01/2017 - 01/2015
2	Hypersensitivity (Allergy) 01/2016 - 07/2012
2	Leukemia 08/2012 - 09/2008
2	Asthma (Bronchial Asthma) 06/2012 - 02/2010
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2012 - 10/2009
2	Hepatocellular Carcinoma (Hepatoma) 09/2011 - 02/2011
2	Inflammation (Inflammations) 10/2008 - 08/2004
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022
1	Drug-Related Side Effects and Adverse Reactions 03/2021
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2020
1	Retinoblastoma (Glioblastoma, Retinal) 12/2019
1	Ventricular Remodeling 12/2019
1	Legionnaires' Disease (Legionnaire's Disease) 01/2019

Drug/Important Bio-Agent (IBA)

31	Phosphotransferases (Kinase)IBA 01/2020 - 08/2002
22	Pharmaceutical PreparationsIBA 01/2022 - 05/2005
15	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2006
9	Sirolimus (Rapamycin)FDA Link 09/2021 - 09/2007
9	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2018 - 04/2008
7	Protein Isoforms (Isoforms)IBA 01/2018 - 04/2008
6	TOR Serine-Threonine KinasesIBA 12/2012 - 10/2008
5	Antiviral Agents (Antivirals)IBA 03/2021 - 03/2009
5	ErbB Receptors (EGF Receptor)IBA 01/2020 - 01/2007
5	Adenosine Triphosphate (ATP)IBA 12/2012 - 03/2007
5	PI103IBA 11/2010 - 05/2006
4	sapanisertibIBA 01/2020 - 02/2012
4	PP242IBA 01/2020 - 03/2010
3	Androgen Receptors (Androgen Receptor)IBA 01/2022 - 10/2007
3	Mechanistic Target of Rapamycin Complex 1IBA 09/2021 - 12/2010
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 08/2012
3	Guanosine Triphosphate (GTP)IBA 10/2020 - 12/2010
3	EnzymesIBA 01/2020 - 05/2006
3	Biological ProductsIBA 01/2019 - 05/2005
3	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2018 - 12/2003
3	Carbonyl Reductase (NADPH)IBA 10/2017 - 02/2011
3	TensinsIBA 01/2017 - 11/2010
3	Dasatinib (BMS 354825)FDA Link 01/2016 - 01/2015
3	DNA (Deoxyribonucleic Acid)IBA 09/2014 - 04/2006
3	LipidsIBA 08/2014 - 01/2007
2	AndrogensIBA 01/2022 - 10/2007
2	Monomeric GTP-Binding ProteinsIBA 01/2022 - 11/2013
2	Oncogene Proteins (Oncogene Protein)IBA 01/2021 - 10/2009
2	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 12/2019 - 11/2015
2	LigandsIBA 11/2019 - 10/2013
2	LDL Lipoproteins (beta Lipoproteins)IBA 01/2018 - 01/2018
2	Proprotein Convertase 9IBA 01/2018 - 01/2018
2	Aurora Kinase AIBA 01/2018 - 04/2016
2	calcium-dependent protein kinaseIBA 12/2017 - 04/2013
2	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2017 - 02/2011
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2017 - 11/2010
2	Mitogen-Activated Protein KinasesIBA 01/2017 - 01/2010
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2017 - 11/2015
2	Small Interfering RNA (siRNA)IBA 01/2016 - 02/2011
2	Biomarkers (Surrogate Marker)IBA 01/2015 - 05/2012
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2014 - 01/2009
2	epidermal growth factor receptor VIIIIBA 10/2013 - 05/2012
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 05/2012 - 09/2007
2	Tyrosine Kinase InhibitorsIBA 01/2010 - 01/2007
2	Imatinib Mesylate (Gleevec)FDA Link 10/2008 - 09/2008
1	plitidepsin (aplidine)IBA 01/2021
1	Guanosine Diphosphate (GDP)IBA 10/2020
1	N- (3- chloro- 7- indolyl)- 1,4- benzenedisulphonamide (E7070)IBA 10/2020
1	SulfonamidesIBA 10/2020
1	RNA Splicing FactorsIBA 10/2020
1	Messenger RNA (mRNA)IBA 10/2020
1	RNA Precursors (Precursor, mRNA)IBA 10/2020
1	CytokinesIBA 01/2020
1	Viral ProteinsIBA 01/2020
1	p38 Mitogen-Activated Protein KinasesIBA 01/2020
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2020
1	Ku 0063794IBA 01/2020
1	VaccinesIBA 01/2020
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2020
1	Casein Kinase II (Casein Kinase 2)IBA 01/2020
1	BetacellulinIBA 01/2020
1	Adenosine KinaseIBA 12/2019
1	palbociclibIBA 12/2019
1	triphosphoric acid (triphosphate)IBA 12/2019
1	calpastatinIBA 12/2019
1	CalpainIBA 12/2019
1	Bacterial Proteins (Bacterial Protein)IBA 01/2019
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2019
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2019
1	Mutant Proteins (Protein, Mutant)IBA 01/2019
1	GuanosineIBA 01/2019

Therapy/Procedure

28	Therapeutics 01/2022 - 12/2003
3	Drug Therapy (Chemotherapy) 01/2016 - 04/2008
2	Radiotherapy 02/2015 - 04/2006
1	Castration 10/2020